RGD Gene Chemical Interaction Report

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	62396
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Ddit3
Name:	DNA-damage inducible transcript 3

Acc ID:	CHEBI:35456
Term:	cadmium dichloride
Definition:	A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID:	MESH:D019256

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	Cadmium Chloride results in increased expression of DDIT3 mRNA, Cadmium Chloride results in increased expression of DDIT3 protein	PMID:11171528, PMID:11958953, PMID:17464326, PMID:21908765, PMID:25409916
multiple interactions	EXP		6480464	CTD	[Cadmium Chloride co-treated with Potassium Dichromate] results in increased expression of DDIT3 mRNA, MT1 affects the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA], MT2 affects the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA], MT3 affects the reaction [Cadmium Chloride affects the expression of DDIT3 mRNA], Phenylbutyrates inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]	PMID:11958953, PMID:20371981, PMID:21908765, PMID:25409916
increases expression	ISO	RGD:62391	6480464	CTD	Cadmium Chloride results in increased expression of DDIT3 mRNA	PMID:20459685, PMID:22110744
increases expression	ISO	RGD:69165	6480464	CTD	Cadmium Chloride results in increased expression of DDIT3 mRNA, Cadmium Chloride results in increased expression of DDIT3 protein	PMID:11678604, PMID:19013231, PMID:21809093, PMID:25374377, PMID:25596134, PMID:26525392, PMID:30796460
multiple interactions	ISO	RGD:62391	6480464	CTD	alpha-Tocopherol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA], Cadmium Chloride promotes the reaction [DDIT3 protein binds to TCF4 protein]	PMID:20459685
multiple interactions	ISO	RGD:69165	6480464	CTD	FBXO6 protein inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein], salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]	PMID:21809093, PMID:25374377

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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