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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of DDIT3 mRNA, Cadmium Chloride results in increased expression of DDIT3 protein

PMID:11171528, PMID:11958953, PMID:17464326, PMID:21908765, PMID:25409916
multiple interactionsEXP 6480464CTD[Cadmium Chloride co-treated with Potassium Dichromate] results in increased expression of DDIT3 mRNA, MT1 affects the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA], MT2 affects the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA], MT3 affects the reaction [Cadmium Chloride affects the expression of DDIT3 mRNA], Phenylbutyrates inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]

PMID:11958953, PMID:20371981, PMID:21908765, PMID:25409916
increases expressionISORGD:623916480464CTDCadmium Chloride results in increased expression of DDIT3 mRNA

PMID:20459685, PMID:22110744
increases expressionISORGD:691656480464CTDCadmium Chloride results in increased expression of DDIT3 mRNA, Cadmium Chloride results in increased expression of DDIT3 protein

PMID:11678604, PMID:19013231, PMID:21809093, PMID:25374377, PMID:25596134, PMID:26525392, PMID:30796460
multiple interactionsISORGD:623916480464CTDalpha-Tocopherol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA], Cadmium Chloride promotes the reaction [DDIT3 protein binds to TCF4 protein]

PMID:20459685
multiple interactionsISORGD:691656480464CTDFBXO6 protein inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein], salubrinal inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]

PMID:21809093, PMID:25374377
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.