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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis inducing factor, mitochondria associated 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1affects localizationEXP 6480464CTDCadmium Chloride affects the localization of AIFM1 proteinPMID:16597613
Aifm1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of AIFM1 proteinPMID:28457857
Aifm1increases secretionEXP 6480464CTDCadmium Chloride results in increased secretion of AIFM1 proteinPMID:16809017
Aifm1affects localizationISOAifm1 (Mus musculus)6480464CTDCadmium Chloride affects the localization of AIFM1 proteinPMID:18506790 PMID:36731763
Aifm1multiple interactionsISOAIFM1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AIFM1 mRNAPMID:35301059
Aifm1multiple interactionsISOAifm1 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]; Cyclosporine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]; KN 93 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]; SB 203580 inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]PMID:18506790 PMID:36731763
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