GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sp1 | decreases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in decreased expression of SP1 mRNA; Cadmium Chloride results in decreased expression of SP1 protein | PMID:33865896 | Sp1 | increases cleavage | EXP | | 6480464 | CTD | Cadmium Chloride results in increased cleavage of SP1 protein | PMID:12499119 | Sp1 | increases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in increased expression of SP1 mRNA | PMID:35525383 | Sp1 | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA]; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein]; bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein]; Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein | PMID:12499119 PMID:35384129 | Sp1 | affects response to substance | ISO | SP1 (Homo sapiens) | 6480464 | CTD | SP1 affects the susceptibility to Cadmium Chloride | PMID:18556457 | Sp1 | multiple interactions | ISO | Sp1 (Mus musculus) | 6480464 | CTD | Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]; Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A2 promoter]; Cadmium Chloride inhibits the reaction [SP1 protein binds to SP3 protein binds to KLF4 protein binds to E2F1 protein binds to NECTIN2 promoter]; zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]] | PMID:20060848 PMID:25046863 | Sp1 | multiple interactions | ISO | SP1 (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein; [SLC39A8 mutant form results in decreased expression of SP1] which affects the susceptibility to Cadmium Chloride; [SLC39A8 mutant form results in decreased expression of SP1] which results in decreased uptake of Cadmium Chloride; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA]; [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein]; SP1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSD11B2 protein] | PMID:18556457 PMID:35384129 | | ||||||||||||||||||||||
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