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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3602
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6
Name: ribosomal protein S6
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of RPS6 mRNAPMID:21297351
Rps6increases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of RPS6 proteinPMID:21544200
Rps6multiple interactionsEXP 6480464CTDEgtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein]PMID:21544200
Rps6increases phosphorylationISORps6 (Mus musculus)6480464CTDCadmium Chloride results in increased phosphorylation of RPS6 proteinPMID:21544200
Rps6multiple interactionsISORPS6 (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of RPS6 mRNAPMID:28342888 PMID:35301059
Rps6multiple interactionsISORps6 (Mus musculus)6480464CTD[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein; Egtazic Acid inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6 protein]; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of RPS6 protein]PMID:21544200 PMID:28342888
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