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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDCadmium Chloride affects the expression of HMOX1 mRNA

PMID:16948784, PMID:20107868, PMID:21442002, PMID:22954530
decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of HMOX1 protein

PMID:26462792
increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of HMOX1, Cadmium Chloride results in increased expression of HMOX1 mRNA, Cadmium Chloride results in increased expression of HMOX1 protein

PMID:15582353, PMID:17483498, PMID:18636176, PMID:19010381, PMID:19682480, PMID:20197452, PMID:20942796, PMID:21236285, PMID:21297351, PMID:22110744, PMID:24401988, PMID:25993096, PMID:30606898, PMID:9152014
multiple interactionsEXP 6480464CTD[spermine nitric oxide complex results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to Cadmium Chloride, Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Grape Seed Proanthocyanidins inhibits the reaction [Cadmium Chloride results in decreased expression of HMOX1 protein], HMOX1 affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride], Melatonin inhibits the reaction [Cadmium Chloride affects the expression of HMOX1 mRNA], Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], NFE2L2 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]

PMID:15582353, PMID:16948784, PMID:19682480, PMID:20197452, PMID:24401988, PMID:26462792, PMID:9152014
affects expressionISORGD:107176480464CTDCadmium Chloride affects the expression of HMOX1 mRNA

PMID:16842966
increases activityISORGD:7309016480464CTDCadmium Chloride results in increased activity of HMOX1 protein

PMID:20934533
increases expressionISORGD:107176480464CTDCadmium Chloride results in increased expression of HMOX1 mRNA, Cadmium Chloride results in increased expression of HMOX1 protein

PMID:10874044, PMID:11051100, PMID:11958953, PMID:12441344, PMID:15081267, PMID:15220209, PMID:15501611, PMID:15504458, PMID:16183037, PMID:16274885, PMID:16517059, PMID:17499415, PMID:18271013, PMID:18512965, PMID:21908765, PMID:22677785, PMID:22914987, PMID:23085594, PMID:23503628, PMID:25409916, PMID:25528414, PMID:25690736, PMID:7538129
increases expressionISORGD:7309016480464CTDCadmium Chloride results in increased expression of HMOX1 mRNA, Cadmium Chloride results in increased expression of HMOX1 protein

PMID:10403520, PMID:10874044, PMID:11592956, PMID:12160620, PMID:15878868, PMID:16959797, PMID:17156779, PMID:17547211, PMID:19952508, PMID:20054154, PMID:20934533, PMID:21787730, PMID:22659318, PMID:23811327, PMID:24291162, PMID:25170436, PMID:25596134, PMID:26260164, PMID:26525392, PMID:28229933, PMID:30572105, PMID:9545559, PMID:9722676, PMID:9747510
multiple interactionsISORGD:107176480464CTD[Cadmium Chloride co-treated with Potassium Dichromate] results in increased expression of HMOX1 mRNA, [Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA, [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein, [HTT gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of HMOX1 protein, [MT1 gene mutant form co-treated with MT2 gene mutant form] promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Ascorbic Acid inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], BACH1 gene mutant form promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA], Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Cadmium Chloride promotes the reaction [BACH1 gene mutant form results in increased expression of HMOX1 mRNA], Cadmium Chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter], Cadmium Chloride results in increased expression of and results in increased activity of HMOX1 protein, CTH protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 protein], Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], HMOX1 enhancer affects the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], MAPK14 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], MT1 affects the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], MT1 gene mutant form promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], MT2 affects the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], MT2 gene mutant form promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], MTF1 gene mutant form promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], NFE2L2 gene mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], NFE2L2 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]

PMID:10874044, PMID:11051100, PMID:11958953, PMID:12441344, PMID:16183037, PMID:16274885, PMID:16517059, PMID:17606337, PMID:18271013, PMID:18512965, PMID:22914987, PMID:23085594, PMID:25409916, PMID:26827822, PMID:30399392, PMID:31166132, PMID:7538129
multiple interactionsISORGD:7309016480464CTD1, 10-phenanthroline inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], 1, 2-Dihydroxybenzene-3, 5-Disulfonic Acid Disodium Salt inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein], 1, 2-Dihydroxybenzene-3, 5-Disulfonic Acid Disodium Salt inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], 1, 2-Dihydroxybenzene-3, 5-Disulfonic Acid Disodium Salt inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], 2, 2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], 2, 2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of HMOX1 mRNA, [Cadmium Chloride co-treated with sodium arsenite] results in increased expression of HMOX1 mRNA, [Cadmium Chloride co-treated with titanium dioxide] results in increased expression of HMOX1 mRNA, [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMOX1 mRNA, acetovanillone inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein], acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], acetovanillone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], Allopurinol inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], calphostin C inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], Deferoxamine inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein], Deferoxamine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Deferoxamine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], diacetyldichlorofluorescein inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], diacetyldichlorofluorescein inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein], diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], ferrous sulfate inhibits the reaction [2, 2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]], ferrous sulfate inhibits the reaction [2, 2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]], ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]], ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]], Genistein inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Genistein promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], Glutathione inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], herbimycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Ketoconazole inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein], NFE2L2 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA], Rotenone inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]

PMID:10874044, PMID:16959797, PMID:20054154, PMID:20934533, PMID:21671166, PMID:22659318, PMID:25170436, PMID:26472158, PMID:29741670, PMID:9545559, PMID:9722676, PMID:9747510
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.