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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CYP1A1 mRNAPMID:22127542 PMID:23135549
Cyp1a1multiple interactionsEXP 6480464CTD11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol inhibits the reaction [Cadmium Chloride results in decreased expression of CYP1A1 mRNA]; [Cadmium Chloride co-treated with 11-fluoro-7-(14,14,15,15-pentafluoro-6-methyl-10-thia-6-azapentadecyl)estra-1,3-5(10)-triene-3,17-diol] results in decreased expression of CYP1A1 mRNA; [Ethinyl Estradiol co-treated with Cadmium Chloride] results in decreased expression of CYP1A1 mRNA; Cadmium Chloride inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP1A1 mRNA]; Estradiol promotes the reaction [Cadmium Chloride results in decreased expression of CYP1A1 mRNA]PMID:22127542 PMID:23135549
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased activity of CYP1A1 proteinPMID:19477068
Cyp1a1decreases expressionISOCyp1a1 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of CYP1A1 mRNAPMID:16517059
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of CYP1A1 mRNAPMID:23135549 PMID:25596134
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDCadmium Chloride results in increased expression of CYP1A1 mRNAPMID:17606337 PMID:23503628
Cyp1a1increases stabilityISOCyp1a1 (Mus musculus)6480464CTDCadmium Chloride results in increased stability of CYP1A1 proteinPMID:17606337
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTD[Buthionine Sulfoximine co-treated with Cadmium Chloride] results in increased expression of CYP1A1 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYP1A1 mRNA; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Cadmium Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 mRNA]; Cadmium Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Cycloheximide promotes the reaction [Cadmium Chloride results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of CYP1A1 mRNA]PMID:16274885 PMID:16517059 PMID:17606337 PMID:37325564
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CYP1A1 mRNA; Cadmium Chloride inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A1 protein]; Cadmium Chloride inhibits the reaction [benz(a)anthracene results in increased activity of CYP1A1 protein]; Cadmium Chloride inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Cadmium Chloride inhibits the reaction [benzo(b)fluoranthene results in increased activity of CYP1A1 protein]; Cadmium Chloride inhibits the reaction [benzo(k)fluoranthene results in increased activity of CYP1A1 protein]; Cadmium Chloride inhibits the reaction [benzo(k)fluoranthene results in increased expression of CYP1A1 protein]; Cadmium Chloride inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP1A1 mRNA]; Cadmium Chloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:11162773 PMID:11408366 PMID:19477068 PMID:23135549 PMID:29741670
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