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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of H2AX proteinPMID:22457795
H2axincreases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of H2AX proteinPMID:37451666
H2axmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein; [Cadmium Chloride results in increased localization of ATM protein] which results in increased phosphorylation of H2AX protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein]; Cadmium Chloride results in increased expression of and results in increased phosphorylation of H2AX proteinPMID:33031904 PMID:37451666
H2axaffects expressionISOH2ax (Mus musculus)6480464CTDCadmium Chloride affects the expression of H2AX mRNAPMID:18974090
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