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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553531
Species: Mus musculus
RGD Object: Gene
Symbol: Rac1
Name: Rac family small GTPase 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rac1increases expressionISORAC1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of RAC1 mRNA; Cadmium Chloride results in increased expression of RAC1 protein; Cadmium Chloride results in increased expression of RAC1 protein modified formPMID:21195169 PMID:28527916 PMID:33129824
Rac1increases expressionISORac1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of RAC1 proteinPMID:21195169
Rac1multiple interactionsISORac1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein]; AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein]; PTEN inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of RAC1 protein]PMID:21195169
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