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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14282980
Species: Sus scrofa
RGD Object: Gene
Symbol: XBP1
Name: X-box binding protein 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XBP1increases splicingEXP 6480464CTDCadmium Chloride results in increased splicing of XBP1 mRNAPMID:17464326 PMID:18086661
XBP1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of XBP1 mRNA alternative form; SOD2 inhibits the reaction [Cadmium Chloride results in increased splicing of XBP1 mRNA]; XBP1 affects the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]PMID:18086661 PMID:33891997
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