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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352552
Species: Homo sapiens
RGD Object: Gene
Symbol: HAVCR1
Name: hepatitis A virus cellular receptor 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HAVCR1increases exportISOHavcr1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased export of HAVCR1 proteinPMID:29421648
HAVCR1increases expressionISOHavcr1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of HAVCR1 mRNA; Cadmium Chloride results in increased expression of HAVCR1 proteinPMID:19371613 PMID:24200859
HAVCR1increases methylationISOHavcr1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of HAVCR1 promoterPMID:22457795
HAVCR1multiple interactionsISOHavcr1 (Rattus norvegicus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HAVCR1 protein; Curcumin inhibits the reaction [Cadmium Chloride results in increased export of HAVCR1 protein]; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HAVCR1 protein]; tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of HAVCR1 protein]PMID:24200859 PMID:29421648 PMID:35384154
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