GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | RETN | decreases expression | ISO | Retn (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in decreased expression of RETN mRNA | PMID:19666079 PMID:23921151 | RETN | increases methylation | ISO | Retn (Rattus norvegicus) | 6480464 | CTD | Cadmium Chloride results in increased methylation of RETN promoter | PMID:22457795 | RETN | multiple interactions | ISO | Retn (Mus musculus) | 6480464 | CTD | [MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of RETN mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of RETN mRNA; MT1 gene mutant form promotes the reaction [Cadmium Chloride results in decreased expression of RETN mRNA]; MT2 gene mutant form promotes the reaction [Cadmium Chloride results in decreased expression of RETN mRNA] | PMID:23921151 | |
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