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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349693
Species: Homo sapiens
RGD Object: Gene
Symbol: RETN
Name: resistin
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RETNdecreases expressionISORetn (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of RETN mRNAPMID:19666079 PMID:23921151
RETNincreases methylationISORetn (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of RETN promoterPMID:22457795
RETNmultiple interactionsISORetn (Mus musculus)6480464CTD[MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of RETN mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in decreased expression of RETN mRNA; MT1 gene mutant form promotes the reaction [Cadmium Chloride results in decreased expression of RETN mRNA]; MT2 gene mutant form promotes the reaction [Cadmium Chloride results in decreased expression of RETN mRNA]PMID:23921151
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