GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HSPA1A | affects expression | EXP | | 6480464 | CTD | Cadmium Chloride affects the expression of HSPA1A mRNA | PMID:23828170 | HSPA1A | decreases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in decreased expression of HSPA1A protein | PMID:26220685 | HSPA1A | increases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in increased expression of HSPA1A mRNA; Cadmium Chloride results in increased expression of HSPA1A protein | PMID:12160620 PMID:15033544 PMID:16729991 PMID:25882684 PMID:26525392 | HSPA1A | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA1A mRNA | PMID:31738976 | HSPA1A | decreases expression | ISO | Hspa1a (Rattus norvegicus) | 6480464 | CTD | Cadmium Chloride results in decreased expression of HSPA1A mRNA | PMID:31077537 | HSPA1A | decreases methylation | ISO | Hspa1a (Rattus norvegicus) | 6480464 | CTD | Cadmium Chloride results in decreased methylation of HSPA1A promoter | PMID:22457795 | HSPA1A | increases expression | ISO | Hspa1a (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in increased expression of HSPA1A mRNA; Cadmium Chloride results in increased expression of HSPA1A protein | PMID:12085988 PMID:18348256 PMID:20061341 | HSPA1A | increases expression | ISO | Hspa1a (Rattus norvegicus) | 6480464 | CTD | Cadmium Chloride results in increased expression of HSPA1A mRNA; Cadmium Chloride results in increased expression of HSPA1A protein | PMID:16729991 PMID:19010381 | HSPA1A | multiple interactions | ISO | Hspa1a (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPA1A mRNA; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAP2K7 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK11 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]; MAPK11 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK12 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]; MAPK12 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK14 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK14 mutant form inhibits the reaction [MAP2K7 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]; MAPK3 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK8 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK9 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein] | PMID:18348256 PMID:37325564 | HSPA1A | multiple interactions | ISO | Hspa1a (Rattus norvegicus) | 6480464 | CTD | [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPA1A mRNA | PMID:31077537 | |
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