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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aaffects expressionEXP 6480464CTDCadmium Chloride affects the expression of HSPA1A mRNAPMID:23828170
HSPA1Adecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of HSPA1A proteinPMID:26220685
HSPA1Aincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of HSPA1A mRNA; Cadmium Chloride results in increased expression of HSPA1A proteinPMID:12160620 PMID:15033544 PMID:16729991 PMID:25882684 PMID:26525392
HSPA1Amultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA1A mRNAPMID:31738976
HSPA1Adecreases expressionISOHspa1a (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of HSPA1A mRNAPMID:31077537
HSPA1Adecreases methylationISOHspa1a (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased methylation of HSPA1A promoterPMID:22457795
HSPA1Aincreases expressionISOHspa1a (Mus musculus)6480464CTDCadmium Chloride results in increased expression of HSPA1A mRNA; Cadmium Chloride results in increased expression of HSPA1A proteinPMID:12085988 PMID:18348256 PMID:20061341
HSPA1Aincreases expressionISOHspa1a (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of HSPA1A mRNA; Cadmium Chloride results in increased expression of HSPA1A proteinPMID:16729991 PMID:19010381
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPA1A mRNA; [MAP2K4 co-treated with MAP2K7] affects the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAP2K7 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK11 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]; MAPK11 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK12 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]; MAPK12 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK14 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK14 mutant form inhibits the reaction [MAP2K7 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]; MAPK3 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK8 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]; MAPK9 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]PMID:18348256 PMID:37325564
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTD[Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of HSPA1A mRNAPMID:31077537
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