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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347076
Species: Homo sapiens
RGD Object: Gene
Symbol: SNAI1
Name: snail family transcriptional repressor 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SNAI1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of SNAI1 mRNA; Cadmium Chloride results in increased expression of SNAI1 proteinPMID:25118938 PMID:30998937 PMID:34905088
SNAI1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SNAI1 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SNAI1 protein]; MIR30E mRNA inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 mRNA]; MIR30E mRNA inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]; NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]; SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]; SNAI1 mutant form inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]PMID:25118938 PMID:30998937 PMID:34687772
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