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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344540
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1RN
Name: interleukin 1 receptor antagonist
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1RNdecreases expressionISOIl1rn (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of IL1RN mRNAPMID:20061341
IL1RNincreases methylationISOIl1rn (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of IL1RN promoterPMID:22457795
IL1RNmultiple interactionsISOIl1rn (Rattus norvegicus)6480464CTDIL1RN protein inhibits the reaction [[sodium arsenite co-treated with Cadmium Chloride co-treated with lead acetate] results in increased cleavage of CASP9 protein]PMID:26396915
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