GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NLRP3 | increases expression | EXP | | 6480464 | CTD | Cadmium Chloride results in increased expression of NLRP3 mRNA; Cadmium Chloride results in increased expression of NLRP3 protein | PMID:30796460 | NLRP3 | multiple interactions | EXP | | 6480464 | CTD | 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP1 protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased secretion of IL18 protein]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [Cadmium Chloride results in increased expression of IL1B mRNA]; NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; NLRP3 protein promotes the reaction [[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased cleavage of IL1B protein]; pyrazolanthrone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein]; SB 203580 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein]; SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA]; STF 083010 inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein]; U 0126 inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein]; XBP1 protein affects the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA]; XBP1 protein alternative form inhibits the reaction [SIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein]] | PMID:26809137 PMID:30796460 PMID:34510229 PMID:37300869 | NLRP3 | increases expression | ISO | Nlrp3 (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in increased expression of NLRP3 protein | PMID:30796460 | NLRP3 | multiple interactions | ISO | Nlrp3 (Rattus norvegicus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein] | PMID:34510229 PMID:35384154 | NLRP3 | multiple interactions | ISO | Nlrp3 (Mus musculus) | 6480464 | CTD | 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 mRNA]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in increased expression of NLRP3 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of NLRP3 protein | PMID:30796460 PMID:33359024 | | ||||||||||||||||||||||
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