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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315921
Species: Homo sapiens
RGD Object: Gene
Symbol: ERCC1
Name: ERCC excision repair 1, endonuclease non-catalytic subunit
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ERCC1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of ERCC1 mRNA; Cadmium Chloride results in decreased expression of ERCC1 proteinPMID:22112500 PMID:26472689
ERCC1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of ERCC1 proteinPMID:26220685
ERCC1increases methylationEXP 6480464CTDCadmium Chloride results in increased methylation of ERCC1 promoterPMID:22112500
ERCC1multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of ERCC1 mRNA; [Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of ERCC1 promoter; decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of ERCC1 mRNA]; decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of ERCC1 protein]PMID:22112500
ERCC1decreases expressionISOErcc1 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of ERCC1 mRNAPMID:15501611
ERCC1increases expressionISOErcc1 (Mus musculus)6480464CTDCadmium Chloride results in increased expression of ERCC1 mRNAPMID:11958953
ERCC1multiple interactionsISOErcc1 (Mus musculus)6480464CTDMT1 affects the reaction [Cadmium Chloride results in increased expression of ERCC1 mRNA]; MT2 affects the reaction [Cadmium Chloride results in increased expression of ERCC1 mRNA]PMID:11958953
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