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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313525
Species: Homo sapiens
RGD Object: Gene
Symbol: MKI67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MKI67increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of MKI67 mRNAPMID:26472689
MKI67multiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of MKI67 mRNAPMID:29741670
MKI67decreases expressionISOMki67 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of MKI67 mRNA; Cadmium Chloride results in decreased expression of MKI67 proteinPMID:25993096 PMID:30506660
MKI67decreases expressionISOMki67 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of MKI67 mRNAPMID:24982889
MKI67increases expressionISOMki67 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of MKI67 proteinPMID:22081424 PMID:22457795
MKI67multiple interactionsISOMki67 (Rattus norvegicus)6480464CTDdecitabine inhibits the reaction [Cadmium Chloride results in increased expression of MKI67 protein]PMID:22457795
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