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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1304921
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdc27
Name: cell division cycle 27
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13126396480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Cadmium Chloride promotes the reaction [CDC20 protein binds to CDC27 protein binds to MAD2L1 protein]], Cadmium Chloride promotes the reaction [CDC20 protein binds to CDC27 protein binds to MAD2L1 protein], CDC27 mutant form inhibits the reaction [Cadmium Chloride results in increased ubiquitination of and results in increased degradation of CDC20 protein]

PMID:20054826
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.