Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of TNF mRNAPMID:23503628 PMID:23921151 PMID:28666365
Tnfincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of TNF; Cadmium Chloride results in increased expression of TNF mRNA; Cadmium Chloride results in increased expression of TNF proteinPMID:11031323 PMID:21620867 PMID:22271428 PMID:23038000 PMID:23948867 PMID:25528414 PMID:26352046 PMID:34743973 PMID:35844137 PMID:35983679 PMID:7536360
Tnfincreases secretionEXP 6480464CTDCadmium Chloride results in increased secretion of TNF proteinPMID:7536360
Tnfmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein; [NFE2L2 protein affects the susceptibility to [Cadmium Chloride results in increased abundance of Cadmium]] which results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; butane-2,3-dione thiosemicarbazone oxime inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; caffeic acid phenethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; fargesin inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Gefitinib inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Gefitinib inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Cadmium Chloride results in increased secretion of TNF protein]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]PMID:21620867 PMID:23038000 PMID:23948867 PMID:32917723 PMID:33359024 PMID:33398418 PMID:34743973 PMID:35844137 PMID:35983679 PMID:7536360
Tnfdecreases methylationISOTnf (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased methylation of TNF promoterPMID:22457795
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of TNF; Cadmium Chloride results in increased expression of TNF mRNA; Cadmium Chloride results in increased expression of TNF proteinPMID:15033544 PMID:18560533 PMID:21605009 PMID:30796460 PMID:35650140 PMID:9707512
Tnfincreases expressionISOTnf (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of TNF; Cadmium Chloride results in increased expression of TNF mRNA; Cadmium Chloride results in increased expression of TNF proteinPMID:19150641 PMID:21819444 PMID:22457795 PMID:24954678 PMID:25446329 PMID:28110594 PMID:32392679 PMID:36493885
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDCadmium Chloride results in increased secretion of TNF proteinPMID:21842098 PMID:30572105 PMID:30796460 PMID:35650140
Tnfincreases secretionISOTnf (Rattus norvegicus)6480464CTDCadmium Chloride results in increased secretion of TNF proteinPMID:7536360
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased secretion of TNF protein; Cadmium Chloride inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; MitoTEMPO inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF mRNA]; TNF affects the reaction [Cadmium Chloride results in increased expression of ADAM8 mRNA]; TNF affects the reaction [Cadmium Chloride results in increased expression of CXCL8 mRNA]; TNF affects the reaction [Cadmium Chloride results in increased expression of EDN1 mRNA]; TNF affects the reaction [Cadmium Chloride results in increased expression of IL13RA2 mRNA]; TNF affects the reaction [Cadmium Chloride results in increased expression of IL24 mRNA]; TNF affects the reaction [Cadmium Chloride results in increased expression of PTGS2 mRNA]; TNF affects the reaction [Cadmium Chloride results in increased expression of SERPINB2 mRNA]PMID:11076874 PMID:18560533 PMID:26809137 PMID:32917723 PMID:34510229 PMID:36602393
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of TNF protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein; [lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of TNF protein; [Sodium Selenite co-treated with zinc chloride] affects the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of TNF protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; Cadmium Chloride affects the reaction [COL2A1 protein results in increased expression of TNF protein]; Cadmium Chloride inhibits the reaction [TNF protein affects the localization of CYCS protein]; Cadmium Chloride inhibits the reaction [TNF protein results in increased activity of CASP9 protein]; Cadmium Chloride inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Cadmium Chloride inhibits the reaction [TNF protein results in increased cleavage of BID protein]; Cadmium Chloride inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Chlorogenic Acid inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; dendropanoxide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Fatty Acids, Omega-3 inhibits the reaction [[[nickel chloride results in increased abundance of Nickel] co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of TNF protein]; Fra a 1 allergen, Fragaria ananassa inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; galangin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Hemin inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of TNF mRNA]; protocatechuic acid inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; Sodium Selenite affects the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of TNF protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of TNF protein]; zinc chloride inhibits the reaction [[lead chloride co-treated with Cadmium Chloride co-treated with Mercuric Chloride co-treated with sodium arsenite] results in increased expression of TNF protein]PMID:16263807 PMID:19150641 PMID:21819444 PMID:22457795 PMID:24954678 PMID:26070417 PMID:28110594 PMID:31390532 PMID:31639282 PMID:32392679 PMID:35384154 PMID:36493885 PMID:36646412 PMID:36718047 PMID:36868496
Go Back to source page   Continue to Ontology report