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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10828
Species: Mus musculus
RGD Object: Gene
Symbol: Jun
Name: jun proto-oncogene
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of JUN mRNAPMID:15501611
Junincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of JUN mRNAPMID:11171528 PMID:11353138
Junincreases phosphorylationEXP 6480464CTDCadmium Chloride results in increased phosphorylation of JUN proteinPMID:34998821
Junmultiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN protein]; Cadmium Chloride results in increased phosphorylation of and results in increased expression of JUN protein; CAT inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; LL Z1640-2 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased expression of JUN protein]; Ro 31-8220 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]PMID:11353138 PMID:15081267 PMID:30796935
Junaffects expressionISOJun (Rattus norvegicus)6480464CTDCadmium Chloride affects the expression of JUN mRNAPMID:22110744
Jundecreases expressionISOJun (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of JUN mRNAPMID:21297351
Jundecreases expressionISOJUN (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of JUN mRNAPMID:22041583
Junincreases expressionISOJun (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of JUN mRNA; Cadmium Chloride results in increased expression of JUN proteinPMID:10647914 PMID:11254161 PMID:11769627 PMID:15252869 PMID:15551354 PMID:19010381 PMID:9559875
Junincreases expressionISOJUN (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of JUN; Cadmium Chloride results in increased expression of JUN mRNAPMID:11341981 PMID:17125913 PMID:26525392 PMID:30682495 PMID:32512071 PMID:9043100 PMID:9044050
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDCadmium Chloride results in increased phosphorylation of JUN proteinPMID:25374377
Junmultiple interactionsISOJun (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein; Cadmium Chloride results in increased phosphorylation of and results in increased expression of JUN protein; carnosol inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; JUN mutant form inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; JUN mutant form promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]; pyrazolanthrone promotes the reaction [celastrol inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased phosphorylation of JUN protein]]; SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]PMID:11769627 PMID:15252869 PMID:18021293 PMID:24111524
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with deoxynivalenol] results in increased expression of JUN mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of JUN mRNA; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of JUN]; Buthionine Sulfoximine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; Cadmium Chloride promotes the reaction [ESR1 protein binds to JUN protein]; Cadmium Chloride promotes the reaction [JUN protein binds to CCND1 promoter]; Cadmium Chloride promotes the reaction [JUN protein binds to MYC promoter]; Cadmium Chloride results in increased phosphorylation of and results in increased expression of JUN protein; FBXO6 protein inhibits the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]; Fulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; JUN mutant form inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 mRNA]; JUN mutant form inhibits the reaction [Cadmium Chloride results in increased expression of CCND1 protein]; JUN mutant form inhibits the reaction [Cadmium Chloride results in increased expression of MYC mRNA]; JUN mutant form inhibits the reaction [Cadmium Chloride results in increased expression of MYC protein]; MAPK8 protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of JUN protein]PMID:11341981 PMID:17125913 PMID:18021293 PMID:20219890 PMID:25374377 PMID:30682495 PMID:33309878 PMID:35301059 PMID:9043100
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