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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10322
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn2a
Name: cyclin dependent kinase inhibitor 2A
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2adecreases expressionISOCDKN2A (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of CDKN2A mRNA alternative form; Cadmium Chloride results in decreased expression of CDKN2A proteinPMID:17938735 PMID:23811327 PMID:25448810
Cdkn2adecreases response to substanceISOCDKN2A (Homo sapiens)6480464CTDCDKN2A results in decreased susceptibility to Cadmium ChloridePMID:25448810
Cdkn2aincreases expressionISOCdkn2a (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of CDKN2A proteinPMID:37451666
Cdkn2aincreases methylationISOCDKN2A (Homo sapiens)6480464CTDCadmium Chloride results in increased methylation of CDKN2A promoter alternative formPMID:25448810
Cdkn2amultiple interactionsISOCdkn2a (Rattus norvegicus)6480464CTDSIRT1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CDKN2A protein]PMID:37451666
Cdkn2amultiple interactionsISOCDKN2A (Homo sapiens)6480464CTD[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in increased expression of CDKN2A mRNA; decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CDKN2A mRNA alternative form]; decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CDKN2A protein]; decitabine inhibits the reaction [Cadmium Chloride results in increased methylation of CDKN2A promoter]PMID:12634122 PMID:17938735 PMID:25448810
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