GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ABCB4 | multiple interactions | EXP | | 6480464 | CTD | [1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ABCB4 mRNA | PMID:27344345 | ABCB4 | decreases expression | ISO | Abcb4 (Rattus norvegicus) | 6480464 | CTD | 1-Naphthylisothiocyanate results in decreased expression of ABCB4 mRNA | PMID:27765674 | ABCB4 | increases expression | ISO | Abcb4 (Mus musculus) | 6480464 | CTD | 1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA; 1-Naphthylisothiocyanate results in increased expression of ABCB4 protein | PMID:15913567 PMID:19181614 PMID:19407337 PMID:25655198 PMID:28549656 | ABCB4 | increases expression | ISO | Abcb4 (Rattus norvegicus) | 6480464 | CTD | 1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA | PMID:14623915 PMID:27765674 | ABCB4 | multiple interactions | ISO | Abcb4 (Mus musculus) | 6480464 | CTD | 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]; [NR1H4 protein results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of ABCB4 mRNA; [PPARA protein affects the susceptibility to 1-Naphthylisothiocyanate] which affects the expression of ABCB4 mRNA; alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]; alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 protein]; NFE2L2 promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]] | PMID:15913567 PMID:19181614 PMID:25655198 PMID:28549656 PMID:29968724 PMID:30352267 | | ||||||||||||||||||||||
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