GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gpt | increases activity | EXP | | 6480464 | CTD | 1-Naphthylisothiocyanate results in increased activity of GPT protein | PMID:24633426 PMID:26921287 PMID:27853831 PMID:28549656 PMID:29737914 PMID:32579994 PMID:33400020 PMID:34619301 PMID:36460194 PMID:36787806 | Gpt | increases expression | EXP | | 6480464 | CTD | 1-Naphthylisothiocyanate results in increased expression of GPT protein | PMID:30352267 PMID:32976922 PMID:36008890 PMID:36581201 PMID:37348807 | Gpt | multiple interactions | EXP | | 6480464 | CTD | 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; [3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid co-treated with C188-9 compound] inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; [Mifepristone co-treated with 1-Naphthylisothiocyanate] results in decreased expression of GPT protein; AHR protein affects the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; C188-9 compound inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; Chenodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; NR1H4 protein affects the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; picroside II inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; PPARA protein affects the reaction [pirinixic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]]; SEW2871 inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; tectorigenin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]; ursodoxicoltaurine affects the reaction [NR1H4 protein affects the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]]; ursodoxicoltaurine promotes the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; VWF protein affects the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein] | PMID:27374722 PMID:27853831 PMID:28549656 PMID:29737914 PMID:32579994 PMID:32976922 PMID:33400020 PMID:34619301 PMID:36008890 PMID:36460194 PMID:36581201 PMID:36787806 PMID:37348807 | Gpt | decreases expression | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | 1-Naphthylisothiocyanate results in decreased expression of GPT mRNA | PMID:30723492 | Gpt | increases activity | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | 1-Naphthylisothiocyanate results in increased activity of GPT protein | PMID:24418708 | Gpt | increases expression | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | 1-Naphthylisothiocyanate results in increased expression of GPT protein | PMID:27317372 | Gpt | increases expression | ISO | GPT (Homo sapiens) | 6480464 | CTD | 1-Naphthylisothiocyanate results in increased expression of GPT protein | PMID:36581201 | Gpt | multiple interactions | ISO | Gpt (Rattus norvegicus) | 6480464 | CTD | dioscin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] | PMID:27317372 | Gpt | multiple interactions | ISO | GPT (Homo sapiens) | 6480464 | CTD | 4-methyl-7,8-dihydroxycoumarin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein] | PMID:36581201 | | ||||||||||||||||||||||
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