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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1increases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNAPMID:25380136 PMID:30723492
Col1a1increases expressionISOCol1a1 (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA; 1-Naphthylisothiocyanate results in increased expression of COL1A1 proteinPMID:21037076 PMID:22094456 PMID:24633426 PMID:26921287 PMID:28049044
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTDFGG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]; FGG protein affects the reaction [leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]]; IFNG protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]; leukadherin-1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]; RAG1 gene mutant form inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]; TGFB1 protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]; Tranexamic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of COL1A1 mRNA]PMID:21037076 PMID:24633426 PMID:26921287 PMID:28049044
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