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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2586
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F2r
Name: coagulation factor II (thrombin) receptor
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2rincreases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in increased expression of F2R mRNAPMID:25380136
F2rincreases expressionISOF2r (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in increased expression of F2R mRNAPMID:21037076
F2rmultiple interactionsISOF2r (Mus musculus)6480464CTDF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of CCL2 mRNA]; F2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of ITGB6 mRNA]; F2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA]; F2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein]PMID:21037076
F2rmultiple interactionsISOF2R (Homo sapiens)6480464CTDF2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]]PMID:21037076
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