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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:35299
Term: dibenz[a,h]anthracene
Definition: An ortho-fused polycyclic arene that has formula C22H14.
Chemical ID: MESH:C026486
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3increases metabolic processingISOCYP2B6 (Homo sapiens)6480464CTDCYP2B6 protein results in increased metabolism of 1,2,5,6-dibenzanthracenePMID:8638931
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of CYP2B6 mRNA; [CYP2B6 protein results in increased metabolism of 1,2,5,6-dibenzanthracene] which results in increased chemical synthesis of dibenzoanthracene-3,4-dihydrodiolPMID:17690111 PMID:8638931
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