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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10511
Species: Mus musculus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrincreases phosphorylationISOEgfr (Rattus norvegicus)6480464CTDZinc Sulfate results in increased phosphorylation of EGFR proteinPMID:19946718
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDZinc Sulfate results in increased phosphorylation of EGFR proteinPMID:10564177 PMID:11943669
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTD4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc Sulfate results in increased phosphorylation of EGFR protein]; Zinc Sulfate results in increased phosphorylation of and results in increased activity of EGFR proteinPMID:16410015
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