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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732817
Species: Mus musculus
RGD Object: Gene
Symbol: Slc12a2
Name: solute carrier family 12, member 2
Acc ID: CHEBI:35154
Term: manganese(0)
Definition: An elemental manganese that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc12a2increases expressionISOSlc12a2 (Rattus norvegicus)6480464CTDManganese results in increased expression of SLC12A2 proteinPMID:25817889
Slc12a2increases oxidationISOSlc12a2 (Rattus norvegicus)6480464CTDManganese results in increased oxidation of SLC12A2 proteinPMID:25817889
Slc12a2multiple interactionsISOSlc12a2 (Rattus norvegicus)6480464CTD1,3-dimethylthiourea inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; 1,3-dimethylthiourea inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Bumetanide inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Vitamin E inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Vitamin E inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]PMID:25817889
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