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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fos
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:35154
Term: manganese(0)
Definition: An elemental manganese that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosmultiple interactionsEXP 6480464CTD[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]PMID:17827730
Fosdecreases expressionISOFOS (Homo sapiens)6480464CTDManganese results in decreased expression of FOS proteinPMID:17043766
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDManganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]PMID:22561169
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