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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1561168
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrrk2
Name: leucine-rich repeat kinase 2
Acc ID: CHEBI:35154
Term: manganese(0)
Definition: An elemental manganese that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrrk2increases response to substanceISOLRRK2 (Homo sapiens)6480464CTDLRRK2 mutant form results in increased susceptibility to ManganesePMID:23628791
Lrrk2multiple interactionsISOLRRK2 (Homo sapiens)6480464CTDLRRK2 mutant form results in increased susceptibility to [Manganese co-treated with SLC6A3 protein]PMID:23628791
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