GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | multiple interactions | EXP | | 6480464 | CTD | [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] | PMID:29115570 | PARP1 | increases cleavage | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Manganese results in increased cleavage of PARP1 protein | PMID:25448048 PMID:25791630 | PARP1 | multiple interactions | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | [Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein; PPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein] | PMID:25791630 | | ||||||||||||||||||||||
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