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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317894
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC39A8
Name: solute carrier family 39 member 8
Acc ID: CHEBI:35154
Term: manganese(0)
Definition: An elemental manganese that has formula Mn.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC39A8affects transportEXP 6480464CTDSLC39A8 gene SNP affects the transport of Manganese; SLC39A8 SNP affects the transport of ManganesePMID:26025379 PMID:28917719
SLC39A8increases importISOSlc39a8 (Rattus norvegicus)6480464CTDSLC39A8 protein results in increased import of ManganesePMID:22898811
SLC39A8increases uptakeISOSlc39a8 (Mus musculus)6480464CTDSLC39A8 protein results in increased uptake of ManganesePMID:16638970
SLC39A8multiple interactionsISOSlc39a8 (Rattus norvegicus)6480464CTDManganese inhibits the reaction [SLC39A8 protein results in increased import of Iron]PMID:22898811
SLC39A8multiple interactionsISOSlc39a8 (Mus musculus)6480464CTDManganese inhibits the reaction [SLC39A8 protein results in increased uptake of Cadmium]; SLC39A8 protein results in increased uptake of [Manganese co-treated with Bicarbonates]PMID:16638970
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