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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731056
Species: Homo sapiens
RGD Object: Gene
Symbol: INS
Name: insulin
Acc ID: CHEBI:35033
Term: triphenyl phosphate
Definition: An aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol.
Chemical ID: MESH:C005445
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
INSaffects expressionEXP 6480464CTDtriphenyl phosphate affects the expression of INS proteinPMID:35563431
INSincreases secretionEXP 6480464CTDtriphenyl phosphate results in increased secretion of INS proteinPMID:35563431
INSmultiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of FABP4 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of FABP4 mRNA]; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of CEBPA mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of FABP4 mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of FABP4 protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of LPL mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of LPL protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of PLIN1 mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of PLIN1 protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate analog] results in increased expression of PPARG mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of CEBPA mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of FABP4 mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of FABP4 protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of LPL mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of LPL protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of PLIN1 mRNA; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of PLIN1 protein; [1-Methyl-3-isobutylxanthine co-treated with INS protein co-treated with triphenyl phosphate] results in increased expression of PPARG mRNA; triphenyl phosphate promotes the reaction [Glucose results in increased secretion of INS protein]PMID:28437481 PMID:35563431
INSmultiple interactionsISOIns2 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [triphenyl phosphate promotes the reaction [INS protein results in increased import of Glucose]]; triphenyl phosphate promotes the reaction [INS protein results in increased import of Glucose]PMID:28163246
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