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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:34918
Term: phenyl salicylate
Definition: A benzoate ester that is the phenyl ester of salicylic acid. Also known as salol, it can be formed by heating salicylic acid with phenol and is used in the manufacture of some polymers, lacquers, adhesives, waxes and polishes.
Chemical ID: MESH:C026041
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDphenyl salicylate results in increased activity of ESR1 proteinPMID:22197706
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDphenyl salicylate binds to and results in increased activity of ESR1 proteinPMID:24004914
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