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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737013
Species: Homo sapiens
RGD Object: Gene
Symbol: TLR4
Name: toll like receptor 4
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR4multiple interactionsISOTlr4 (Mus musculus)6480464CTD[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein; Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR4 protein]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PFKP mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of PPARA mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A1 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SLC2A4 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of SREBF1 mRNA]; TLR4 gene mutant form inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased expression of TLR5 protein]PMID:29751049
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