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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352960
Species: Homo sapiens
RGD Object: Gene
Symbol: CES1
Name: carboxylesterase 1
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CES1affects hydrolysisEXP 6480464CTDCES1 protein affects the hydrolysis of PermethrinPMID:18983829
CES1increases hydrolysisEXP 6480464CTDCES1 protein results in increased hydrolysis of PermethrinPMID:16359636 PMID:16387282
CES1increases hydrolysisISOCes1d (Rattus norvegicus)6480464CTDCES1 protein results in increased hydrolysis of PermethrinPMID:16387282
CES1increases hydrolysisISOCes1d (Mus musculus)6480464CTDCES1 protein results in increased hydrolysis of PermethrinPMID:16387282
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