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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:34910
Term: pentetrazol
Definition: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
Chemical ID: MESH:D010433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDPentylenetetrazole results in increased expression of VEGFA proteinPMID:32450180
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDdaidzin inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]; Diazepam inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein]PMID:32450180
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