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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736796
Species: Homo sapiens
RGD Object: Gene
Symbol: DRD2
Name: dopamine receptor D2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DRD2affects expressionISODrd2 (Rattus norvegicus)6480464CTDParaquat affects the expression of DRD2 mRNAPMID:15206577
DRD2decreases expressionISODrd2 (Rattus norvegicus)6480464CTDParaquat results in decreased expression of DRD2 mRNAPMID:34655599
DRD2increases expressionISODrd2 (Rattus norvegicus)6480464CTDParaquat results in increased expression of DRD2 mRNAPMID:18198484
DRD2multiple interactionsISODrd2 (Mus musculus)6480464CTD[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNAPMID:23017109
DRD2multiple interactionsISODrd2 (Rattus norvegicus)6480464CTDnaringenin inhibits the reaction [Paraquat results in decreased expression of DRD2 mRNA]PMID:34655599
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