GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAPT | decreases expression | ISO | Mapt (Rattus norvegicus) | 6480464 | CTD | Paraquat results in decreased expression of MAPT protein | PMID:24521700 | MAPT | increases phosphorylation | ISO | Mapt (Rattus norvegicus) | 6480464 | CTD | Paraquat results in increased phosphorylation of MAPT protein | PMID:31715309 PMID:32738378 | MAPT | multiple interactions | ISO | Mapt (Rattus norvegicus) | 6480464 | CTD | [BDNF protein co-treated with MF63 compound co-treated with Estradiol] inhibits the reaction [Paraquat results in increased phosphorylation of MAPT protein]; [BDNF protein co-treated with MF63 compound] promotes the reaction [Estradiol inhibits the reaction [Paraquat results in increased phosphorylation of MAPT protein]]; BDNF protein inhibits the reaction [Paraquat results in increased phosphorylation of MAPT protein]; Estradiol inhibits the reaction [Paraquat results in increased phosphorylation of MAPT protein]; MF63 compound inhibits the reaction [Paraquat results in increased phosphorylation of MAPT protein] | PMID:31715309 PMID:32738378 | MAPT | multiple interactions | ISO | Mapt (Mus musculus) | 6480464 | CTD | [Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Paraquat results in increased phosphorylation of and results in increased expression of MAPT protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA] | PMID:22292029 PMID:23963992 | | ||||||||||||||||||||||
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