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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733892
Species: Mus musculus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases phosphorylationEXP 6480464CTDParaquat results in decreased phosphorylation of GSK3B proteinPMID:30171970
Gsk3bincreases phosphorylationEXP 6480464CTDParaquat results in increased phosphorylation of GSK3B proteinPMID:24634145
Gsk3bmultiple interactionsEXP 6480464CTDLithium Chloride inhibits the reaction [Paraquat results in decreased phosphorylation of GSK3B protein]; Paraquat results in increased expression of and results in increased phosphorylation of GSK3B proteinPMID:22292029 PMID:30171970
Gsk3bdecreases expressionISOGSK3B (Homo sapiens)6480464CTDParaquat results in decreased expression of GSK3B proteinPMID:28414160
Gsk3bdecreases phosphorylationISOGsk3b (Rattus norvegicus)6480464CTDParaquat results in decreased phosphorylation of GSK3B proteinPMID:34048864 PMID:36394833
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDParaquat results in increased phosphorylation of GSK3B proteinPMID:30205152
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]; Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]; WNT1 protein inhibits the reaction [Paraquat results in decreased phosphorylation of GSK3B protein]PMID:28414160 PMID:30171970
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