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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70501
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2multiple interactionsEXP 6480464CTD[ATG7 protein affects the susceptibility to Paraquat] which affects the expression of CDK2 mRNA; [Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]PMID:23963992 PMID:28012437
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