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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69106
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases response to substanceEXP 6480464CTDNR1I2 gene mutant form results in increased susceptibility to ParaquatPMID:16195250
Nr1i2decreases expressionISONR1I2 (Homo sapiens)6480464CTDParaquat results in decreased expression of NR1I2 proteinPMID:26196221
Nr1i2increases expressionISONR1I2 (Homo sapiens)6480464CTDParaquat results in increased expression of NR1I2 mRNAPMID:34681664
Nr1i2increases response to substanceISONR1I2 (Homo sapiens)6480464CTDNR1I2 protein results in increased susceptibility to ParaquatPMID:16195250
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[NR1I2 protein results in decreased activity of CAT protein] which results in increased susceptibility to ParaquatPMID:16195250
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