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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 6487636
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox1
Name: SRY-box transcription factor 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox1decreases expressionISOSOX1 (Homo sapiens)6480464CTDParaquat results in decreased expression of SOX1 mRNA; Paraquat results in decreased expression of SOX1 proteinPMID:25314302 PMID:30698896
Sox1increases expressionISOSOX1 (Homo sapiens)6480464CTDParaquat results in increased expression of SOX1 mRNAPMID:35182771
Sox1multiple interactionsISOSOX1 (Homo sapiens)6480464CTDParaquat affects the reaction [Bucladesine affects the expression of SOX1 mRNA]; Paraquat affects the reaction [Bucladesine affects the expression of SOX1 protein]PMID:31400064
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