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RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDParaquat results in increased activity of CASP12 protein

increases degradationEXP 6480464CTDParaquat results in increased degradation of CASP12 protein

increases expressionEXP 6480464CTDParaquat results in increased expression of CASP12 mRNA, Paraquat results in increased expression of CASP12 protein

multiple interactionsEXP 6480464CTDMinocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein], NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of CASP12 mRNA]

PMID:22245251, PMID:22678742
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.