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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1amultiple interactionsEXP 6480464CTD[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased expression of PPARGC1A proteinPMID:24376630
Ppargc1adecreases expressionISOPpargc1a (Mus musculus)6480464CTDParaquat results in decreased expression of PPARGC1A proteinPMID:28115273
Ppargc1aincreases expressionISOPpargc1a (Mus musculus)6480464CTDParaquat results in increased expression of PPARGC1A proteinPMID:22563483
Ppargc1aincreases expressionISOPPARGC1A (Homo sapiens)6480464CTDParaquat results in increased expression of PPARGC1A mRNAPMID:35182771
Ppargc1amultiple interactionsISOPpargc1a (Mus musculus)6480464CTDAKT2 protein affects the reaction [Paraquat results in decreased expression of PPARGC1A protein]PMID:28115273
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