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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620893
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaa2
Name: protein kinase AMP-activated catalytic subunit alpha 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkaa2affects response to substanceISOPrkaa2 (Mus musculus)6480464CTDPRKAA2 gene affects the susceptibility to ParaquatPMID:25092649
Prkaa2increases expressionISOPrkaa2 (Mus musculus)6480464CTDParaquat results in increased expression of PRKAA2 proteinPMID:27324791
Prkaa2increases phosphorylationISOPrkaa2 (Mus musculus)6480464CTDParaquat results in increased phosphorylation of PRKAA2 proteinPMID:25092649
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