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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3258
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pax6
Name: paired box 6
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pax6decreases expressionISOPAX6 (Homo sapiens)6480464CTDParaquat results in decreased expression of PAX6 mRNA; Paraquat results in decreased expression of PAX6 proteinPMID:30698896
Pax6multiple interactionsISOPax6 (Mus musculus)6480464CTD[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNAPMID:23017109
Pax6multiple interactionsISOPAX6 (Homo sapiens)6480464CTDParaquat affects the reaction [Bucladesine affects the expression of PAX6 mRNA]; Paraquat affects the reaction [Bucladesine affects the expression of PAX6 protein]PMID:31400064
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