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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615156
Species: Mus musculus
RGD Object: Gene
Symbol: Tnc
Name: tenascin C
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tncincreases expressionEXP 6480464CTDParaquat results in increased expression of TNC mRNA; Paraquat results in increased expression of TNC proteinPMID:26345256 PMID:34463846
Tncincreases expressionISOTNC (Homo sapiens)6480464CTDParaquat results in increased expression of TNC mRNA; Paraquat results in increased expression of TNC proteinPMID:34463846
Tncincreases expressionISOTnc (Rattus norvegicus)6480464CTDParaquat results in increased expression of TNC mRNAPMID:32680482
Tncmultiple interactionsISOTNC (Homo sapiens)6480464CTDTNC protein affects the reaction [Paraquat results in increased expression of and results in increased phosphorylation of RELA protein]; TNC protein affects the reaction [Paraquat results in increased expression of TGFB1 protein]; TNC protein affects the reaction [Paraquat results in increased expression of TLR4 protein]PMID:34463846
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