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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1559716
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signaling 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ern1increases phosphorylationEXP 6480464CTDParaquat results in increased phosphorylation of ERN1 proteinPMID:22245251
Ern1increases expressionISOERN1 (Homo sapiens)6480464CTDParaquat results in increased expression of ERN1 mRNA; Paraquat results in increased expression of ERN1 protein modified formPMID:28986289 PMID:34097952
Ern1increases phosphorylationISOERN1 (Homo sapiens)6480464CTDParaquat results in increased phosphorylation of ERN1 proteinPMID:20929985 PMID:28986289
Ern1multiple interactionsISOERN1 (Homo sapiens)6480464CTDParaquat promotes the reaction [MAP3K5 protein results in increased phosphorylation of ERN1 protein]PMID:20929985
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