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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305742
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tia1
Name: TIA1 cytotoxic granule-associated RNA binding protein
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects splicingISORGD:13139566480464CTDParaquat affects the splicing of TIA1 exon

PMID:27111068
decreases expressionISORGD:13139566480464CTDParaquat results in decreased expression of TIA1 protein

PMID:27111068
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.